http://hdl.handle.net/10339/33221 Fri, 24 May 2013 15:13:39 GMT 2013-05-24T15:13:39Z http://hdl.handle.net/10339/30049 Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers Ying, Maben; Smentek, Matthew G.; Ma, Rong; Day, Cynthia S.; Torti, Suzy V.; Welker, Mark E. A number of alkynols have been prepared by Sonogoshira coupling of propargyl alcohol to disubstituted aromatic halides. Chelation controlled addition of organometallic nucleophiles to these alkynols was then affected followed by the addition of sulfur dioxide. This methodology was used to prepare a number of oxathiolene oxides which have been screened as NQO1 (quinone oxidoreductase) inducers. Thu, 01 Jan 2009 00:00:00 GMT http://hdl.handle.net/10339/30049 2009-01-01T00:00:00Z