Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers

Item Details

contributor

Ying, Maben (author)

Smentek, Matthew G. (author)

Ma, Rong (author)

Day, Cynthia S. (author)

Torti, Suzy V. (author)

Welker, Mark E. (author)

date

2010-11-30T21:40:51Z (accessioned)

2010-11-30T21:40:51Z (available)

2009 (issued)

identifier

Ying, Maben; Smentek, Matthew G.; Ma, Rong; Day, Cynthia S.; Torti, Suzy V.; & Welker, Mark E. Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers. Letters in Organic Chemistry. 2009. 6, 3:242-251. (citation)

http://hdl.handle.net/10339/30049 (uri)

http://www.bentham.org/loc/open-access-articles/loc6-3/013AN.pdf (uri)

description

A number of alkynols have been prepared by Sonogoshira coupling of propargyl alcohol to disubstituted aromatic halides. Chelation controlled addition of organometallic nucleophiles to these alkynols was then affected followed by the addition of sulfur dioxide. This methodology was used to prepare a number of oxathiolene oxides which have been screened as NQO1 (quinone oxidoreductase) inducers. (abstract)

publisher

Bentham Science Publishers

source

Letters in Organic Chemistry

title

Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers

type

Article

citation

3 (issue)

6 (volume)