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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL

Sophonsritsuk, Areepan (Wake Forest University, 2011)

The role of T helper 17 (Th17) cells and interleukin-17A (IL-17A), a signature pro-inflammatory cytokine for Th17, in atherosclerosis is unknown. Postmenopausal estrogen therapy (ET) mediates atheroprotection in part through ...
ROLE OF 12/15 LIPOXYGENASE EXPRESSION IN LIPID METABOLISM, ATHEROSCLEROSIS AND INSULIN RESISTANCE

Rong, Shunxing (Wake Forest University, 2010)

12/15 lipoxygenase (LO) is a member of a family of enzymes that can catalyze the stereospecific incorporation of oxygen into polyunsaturated fatty acids (PUFAs), forming a series of bioactive lipid mediators. Though lipid ...
THE ROLE OF BOTANICAL OILS ENRICHED IN FADS2-DERIVED N-3 VS. N-6 POLYUNSATURATED FATTY ACIDS IN PREVENTION OF ATHEROSCLEROSIS

Shewale, Swapnil Vijay (Wake Forest University, 2015)

Background: Dietary polyunsaturated fatty acids (PUFAs) reduce atherosclerosis in animal models and humans relative to dietary saturated and monounsaturated fatty acids. Although some of the atheroprotection of dietary ...
The Role of Lipid-Free Apolipoprotein A-I and PCPE2 in HDL Metabolism

Pollard, Ricquita DeAnn (Wake Forest University, 2015)

The purpose of this work is to investigate the role of apolipoprotein apoA-I (apoA-I) and procollagen C-endopeptidase enhancer 2 (PCPE2) in high density lipoprotein (HDL) metabolism. ApoA-I comprises ~70 percent of the ...
The Role of OSTalpha/beta in Bile Acid and Lipid Metabolism

Lan, Tian (Wake Forest University, 2013)

Bile acids are synthesized from cholesterol in the liver. Fecal bile acid excretion accounts for nearly half of daily cholesterol disposal. It has been known for many years that ileal resection or blocking intestinal apical ...
Studies of Atherosclerosis in Systemic Lupus Erythematosus

Shelton, Kathryn (Wake Forest University, 2012)

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of anti-nuclear autoantibodies, a wide spectrum of clinical signs, and a striking 9:1 female to male disparity in disease ...

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