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Browsing by Subject "Autoimmunity"

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Differential Mechanisms Underlying Inflammatory Th17 Cells in Autoimmunity and Colitogenic Infection

Bouch, Ronald Jacob (Wake Forest University, 2023)

Th17 cells are a heterogeneous population that are critical for tissue homeostasis and inflammation during clearance of infections and autoimmunity. Substantial efforts have been made to characterize the homeostatic and ...
Structural and Biochemical Examination of Aberrant dsDNA Metabolism in TREX1-associated Autoimmunity

Fye, Jason (Wake Forest University, 2013)

TREX1 is a 3’ exonuclease that degrades both single– and double–stranded polynucleotides in order to facilitate orderly cell death and prevent immune dysfunction. Mutations in the TREX1 gene at positions ...
T CELLS PRODUCE TYPE I INTERFERON IN THE TREX1 D18N MODEL OF CGAS-STING-DEPENDENT INTERFERONOPATHY

Simpson, Sean (Wake Forest University, 2020)

Autoimmunity can result when cells fail to properly dispose of DNA. Mutations in the DNA-degrading Three-prime Repair EXonuclease 1 (TREX1) cause a spectrum of human autoimmune diseases resembling Systemic Lupus Erythematosus ...

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