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Browsing by Author "Salsbury, Freddie R."

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Browsing by Author "Salsbury, Freddie R."

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  • Electrostatics of cysteine residues in proteins: Parameterization and validation of a simple model 
    Salsbury, Freddie R.; Poole, Leslie B.; Fetrow, Jacquelyn S. (Wiley-Blackwell, 2012)
    One of the most popular and simple models for the calculation of pKas from a protein structure is the semi-macroscopic electrostatic model MEAD. This model requires empirical parameters for each residue to calculate pKas. ...
  • Improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment 
    Scarpinato, Karin Drotschmann; AbdelHafez, ElShimaa; Diamanduros, Andrew; Negureanu, Lacramioara; Lu, Yan; Bean, Jessica Hayley; Zielke, Katherine; Crowe, Brittany; Vasilyeva, Aksana; Clodfelter, Jill; Aly, Omar; Abuo-Rahma, Gamal; Salsbury, Freddie R.; King, Stephen Bruce (eOpen Access Publishing, 2013)
    We, and others have previously shown that mismatch repair proteins, in addition to their repair function, have the ability to contribute to cell death initiation. In response to some drugs, this cell death activity is ...