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Browsing by Author "Vasilyeva, Aksana"

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Browsing by Author "Vasilyeva, Aksana"

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  • Improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment 
    Scarpinato, Karin Drotschmann; AbdelHafez, ElShimaa; Diamanduros, Andrew; Negureanu, Lacramioara; Lu, Yan; Bean, Jessica Hayley; Zielke, Katherine; Crowe, Brittany; Vasilyeva, Aksana; Clodfelter, Jill; Aly, Omar; Abuo-Rahma, Gamal; Salsbury, Freddie R.; King, Stephen Bruce (eOpen Access Publishing, 2013)
    We, and others have previously shown that mismatch repair proteins, in addition to their repair function, have the ability to contribute to cell death initiation. In response to some drugs, this cell death activity is ...
  • Targeted Drug Discovery: Targeting a Specific Conformation of MutS/MSH Proteins with Small Molecules 
    Vasilyeva, Aksana (Wake Forest University, 2010)
    Mismatch repair proteins repair mismatches in the DNA and signal cell death in response to certain DNA lesions. Due to these distinct functions of MMR proteins, they are proposed to exist in at least two different ...