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Browsing by Author "Xiao, Jiajie"

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Browsing by Author "Xiao, Jiajie"

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  • CLASSIFYING PEROXIREDOXIN SUBGROUPS AND IDENTIFYING DISCRIMINATING MOTIFS VIA MACHINE LEARNING 
    Xiao, Jiajie (Wake Forest University, 2018)
    Accurate and automated functional annotation is a pressing open problem, with functional characterizations lagging far behind the exponential growth in biological sequence databases. In this thesis, I present our recent ...
  • Combining capillary electrophoresis and next-generation sequencing for aptamer selection 
    Riley, Kathryn R.; Gagliano, Jason; Xiao, Jiajie; Libby, Kara; Saito, Shingo; Yu, Guo; Cubicciotti, Roger; Macosko, Jed; Colyer, Christa L.; Guthold, Martin; Bonin, Keith (Springer, 2015)
    Next-generation sequencing (NGS) machines can sequence millions of DNA strands in a single run, such as oligonucleotide (oligo) libraries comprising millions to trillions of discrete oligo sequences. Capillary electrophoresis ...
  • Combining capillary electrophoresis and next-generation sequencing for aptamer selection 
    Riley, Kathryn R; Gagliano, Jason; Xiao, Jiajie; Libby, Kara; Saito, Shingo; Yu, Guo; Cubiccioti, Roger (Springer, 1/13/15)
    Next-generation sequencing (NGS) machines can sequence millions of DNA strands in a single run, such as oligonucleotide (oligo) libraries comprising millions to trillions of discrete oligo sequences. Capillary electrophoresis ...
  • UNDERSTANDING GENERALIZED ALLOSTERY IN THROMBIN 
    Xiao, Jiajie (Wake Forest University, 2018)
    Thrombin is a critical drug target for chemotherapeutic and antithrombotic therapy development. Although many experiments have demonstrated that thrombin is a multifunctional allosteric enzyme, the exact mechanism of ...