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INSIGHTS INTO THE CHEMICAL BIOLOGY OF REACTIVE SULFUR SPECIES PROVIDED BY NEW INVESTIGATIVE TOOLS

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title
INSIGHTS INTO THE CHEMICAL BIOLOGY OF REACTIVE SULFUR SPECIES PROVIDED BY NEW INVESTIGATIVE TOOLS
author
Suarez, Santiago Israel
abstract
Two decades of research on the signaling capacity of hydrogen sulfide (H2S) in biological systems has led to parallel investigations of other reactive sulfur species (RSS) such as persulfides (RSSH) and polysulfides (RSSnR, n>1). The purpose of this dissertation was to develop and assess new investigative tools that selectively detect or effectively deliver RSS under biologically relevant conditions. These chemical tools are of significant interest to the redox and molecular signaling communities and can be used to further define the prevalence, signaling capacity, and therapeutic effects of RSS, representing a significant advancement within the field.
subject
Hydrogen Sulfide
Reactive Sulfur Species
RSS
contributor
Lukesh, John C. (committee chair)
Bierbach, Ulrich (committee member)
King, Stephen B. (committee member)
Welker, Mark E. (committee member)
date
2022-05-24T08:35:52Z (accessioned)
2023-05-23T08:30:15Z (available)
2022 (issued)
degree
Chemistry (discipline)
embargo
2023-05-23 (terms)
identifier
http://hdl.handle.net/10339/100723 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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