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DEVELOPING PHARMACOLOGICAL TGLI1 INHIBITORS FOR THE TREATMENT OF METASTATIC BREAST CANCER

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title
DEVELOPING PHARMACOLOGICAL TGLI1 INHIBITORS FOR THE TREATMENT OF METASTATIC BREAST CANCER
author
Doheny, Daniel Lawrence
abstract
Breast cancer remains the second leading cause of cancer-related death in women and second most common cancer to metastasize to the brain. Despite improvements in early detection and targeted therapies, breast cancer patients with brain metastases survive a median of 4-6 months underscoring the clinical need to develop new therapeutic strategies and identify novel actionable targets. The aim of this study is to revolutionize breast cancer treatment regimens by characterizing novel combinations of FDA-approved therapies to provide translatable results, and by developing small molecule inhibitors against a key driver of breast cancer brain metastases (BCBM), truncated glioma-associated oncogene homolog 1 (tGLI1).
subject
breast cancer
breast cancer brain metastasis
breast cancer stem cells
GLI1
small molecules
tGLI1
contributor
Lo, Hui-Wen (committee chair)
Metheny-Barlow, Linda J. (committee member)
Furdui, Cristina M. (committee member)
Smalley, Terrence L. (committee member)
Strowd, Roy E. (committee member)
Watabe, Kounosuke (committee member)
date
2022-05-24T08:36:12Z (accessioned)
2024-05-23T08:30:07Z (available)
2022 (issued)
degree
Cancer Biology (discipline)
embargo
2024-05-23 (terms)
identifier
http://hdl.handle.net/10339/100773 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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