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DEVELOPMENT OF SURVIVAL ANALYSIS TO MODEL BIOFILM REACTION TO LASER-INDUCED HYPERTHERMIA

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title
DEVELOPMENT OF SURVIVAL ANALYSIS TO MODEL BIOFILM REACTION TO LASER-INDUCED HYPERTHERMIA
author
Burden, Bradley
abstract
Nosocomial infections are a large clinical problem facing healthcare systems worldwide and are putting those in poor health into even greater danger. These infections, also known as hospital acquired infections (HAIs), are most commonly due to bacteria. They can occur frequently at surgical sites and on implanted medical devices such as catheters. Biofilm-producing bacteria on medical devices prove especially difficult to eradicate due to drug resistance, device material, and device location. Photothermal therapy has recently been explored as a new treatment route but becomes difficult to model at higher temperatures that are sometimes needed to disrupt biofilm. Survival analysis, a type of modeling with previous oncological treatment use, was tested as a future direction for modeling photothermal treatment of biofilm-related infections using E. coli biofilm on silicone, a common medical device material. In order to evaluate its ability to discern more subtle details of the infections, survival analysis was then used to model the reactions of different strains of S. aureus to hyperthermia. Both experiments produced results that will allow further research into survival analysis and photothermal therapy as a treatment for biofilm-related infections.
subject
biofilm
hyperthermia
photothermal
survival analysis
contributor
Gayzik, Scott (committee chair)
Brown, Philip (committee member)
date
2022-09-17T08:35:48Z (accessioned)
2022 (issued)
degree
Biomedical Engineering (discipline)
embargo
2024-09-16 (terms)
2024-09-16 (liftdate)
identifier
http://hdl.handle.net/10339/101259 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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