Item Details

title

DEVELOPMENT OF SURVIVAL ANALYSIS TO MODEL BIOFILM REACTION TO LASER-INDUCED HYPERTHERMIA

author

Burden, Bradley

abstract

Nosocomial infections are a large clinical problem facing healthcare systems worldwide and are putting those in poor health into even greater danger. These infections, also known as hospital acquired infections (HAIs), are most commonly due to bacteria. They can occur frequently at surgical sites and on implanted medical devices such as catheters. Biofilm-producing bacteria on medical devices prove especially difficult to eradicate due to drug resistance, device material, and device location. Photothermal therapy has recently been explored as a new treatment route but becomes difficult to model at higher temperatures that are sometimes needed to disrupt biofilm. Survival analysis, a type of modeling with previous oncological treatment use, was tested as a future direction for modeling photothermal treatment of biofilm-related infections using E. coli biofilm on silicone, a common medical device material. In order to evaluate its ability to discern more subtle details of the infections, survival analysis was then used to model the reactions of different strains of S. aureus to hyperthermia. Both experiments produced results that will allow further research into survival analysis and photothermal therapy as a treatment for biofilm-related infections.

subject

biofilm

hyperthermia

photothermal

survival analysis

contributor

Gayzik, Scott (committee chair)

Brown, Philip (committee member)

date

2022-09-17T08:35:48Z (accessioned)

2024-09-16T08:30:07Z (available)

2022 (issued)

degree

Biomedical Engineering (discipline)

embargo

2024-09-16 (terms)

identifier

http://hdl.handle.net/10339/101259 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis