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INVESTIGATING THE ANTICANCER EFFECTS OF CANNABIDIOL ON DRUG-RESISTANT PROSTATE CANCER CELLS: IMPLICATIONS FOR CHEMOPREVENTION

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title
INVESTIGATING THE ANTICANCER EFFECTS OF CANNABIDIOL ON DRUG-RESISTANT PROSTATE CANCER CELLS: IMPLICATIONS FOR CHEMOPREVENTION
author
He, Yangen
abstract
Cancer has emerged as a daunting public health challenge in the 21st century, with more than 18 million individuals having a cancer history in the United States as of January 1st, 2022. While medical advancements have improved the survival rate of cancer patients, the quality of life of cancer survivors remains a concern. The need for cancer prevention, recurrence preclusion, and pain relief is urgent. Cannabidiol, a natural product, holds promise as a cancer chemopreventive agent and a pain reliever due to its potent anticancer effects and low cytotoxicity. This study investigates the in vivo and in vitro anticancer properties of cannabidiol, revealing its significant growth inhibitory effect on drug-resistant prostate cancer cells through apoptosis induction. In addition, our findings suggest that cannabidiol has the potential to improve the quality of life of prostate cancer patients by relieving pain. We also explore the impact of cannabidiol on the extracellular vesicle biogenesis of cancer cells, which could contribute to its anticancer effects.
subject
cancer chemoprevention
cannabidiol
drug-resistance
prostate cancer
contributor
Deep, Gagan (advisor)
Sai, Kiran K. S. (committee member)
Yammani, Raghunatha (committee member)
date
2023-07-25T17:48:47Z (accessioned)
2023 (issued)
degree
Biomedical Science – MS (discipline)
embargo
2024-06-06 (terms)
2024-06-06 (liftdate)
identifier
http://hdl.handle.net/10339/102281 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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