Item Details

title

Evaluation of Acetylcholine Receptor Agonists as Pharmacotherapies for Alcohol Use Disorder in Group-Housed Monkeys

author

Galbo-Thomma, Lindsey Kay

abstract

In the United States, approximately 9% of the population aged 12 or older met criteria for a past year alcohol use disorder (AUD) in 2020. Only approximately 5% and 1% of this population received any or medication-assisted treatment, respectively, despite the availability of three Food and Drug Administration (FDA)-approved pharmacotherapies. Moreover, AUD patients often exhibit cognitive impairments which can influence motivation to seek treatment, treatment retention and rates of relapse. Fortunately, length of recovery/abstinence is positively correlated with remediation of cognitive impairment. These statistics clearly indicate a critical need for further characterizing the etiology of AUD and investigating novel treatment approaches and pharmacotherapies with greater efficacy than those currently available.

subject

alcohol use disorder

cholinergic pharmacotherapies

chronic stress

cognition

nonhuman primate

contributor

Czoty, Paul W. (advisor)

Czoty, Paul W. (committee member)

Hanlon, Colleen A. (committee member)

Nader, Michael A. (committee member)

Weiner, Jeffery L. (committee member)

Gould, Robert W. (committee member)

date

2023-09-08T08:35:25Z (accessioned)

2024-03-07T09:30:06Z (available)

2023 (issued)

degree

Physiology and Pharmacology (discipline)

embargo

2024-03-07 (terms)

identifier

http://hdl.handle.net/10339/102617 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation