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Relative Protein Content of CB1R and CRIP1a in the Basal Ganglia and Other Brain Regions

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title
Relative Protein Content of CB1R and CRIP1a in the Basal Ganglia and Other Brain Regions
author
Madasamy, Maheshram
abstract
CB1 Cannabinoid Receptor is one of the major receptor subtypes in the endocannabinoid system, which has made it a potential target for therapeutic action. Areas of the brain with higher CB1R expression can include the hippocampus, olfactory bulb, basal ganglia, and cerebellum. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) has been implicated in having a role in cell development, mammalian sensory systems, seizures, neuropsychiatric diseases, and cancer epigenetics. CRIP1a can also alter preference of Gi/o subtypes in signaling and allows for attenuation of agonist-mediated internalization of CB1Rs. Studying for relative density of these proteins can allow for evaluation how much CRIP1a is expressed compared with CB1R in brain regions, which is important for disease and therapeutic implications.
contributor
Howlett, Allyn C. (advisor)
Chen, Rong (committee member)
Romero-Sandoval, Edgar Alfonso (committee member)
date
2024-02-13T09:36:09Z (accessioned)
2024-02-13T09:36:09Z (available)
2024 (issued)
degree
Physiology and Pharmacology (discipline)
identifier
http://hdl.handle.net/10339/102914 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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