Item Details

title

REGULATION OF BREAST CANCER BRAIN METASTASIS BY MICRORNAS

author

Wong, Grace Landes

abstract

Brain metastases are ten times more common than primary brain tumors and occur in 10-30% of breast cancer patients with metastases. Mechanisms that underlie breast cancer brain metastasis (BCBM) are still not well understood; this knowledge gap contributes to poor patient prognoses. The goal of this study is to elucidate pathways that drive BCBM, primarily centering on microRNAs (miRNAs). miRNAs are small noncoding RNAs that regulate gene expression by targeting mRNA transcripts and have been demonstrated to drive key processes in breast cancer metastasis.

subject

Astrocytes

Brain microenvironment

Breast cancer

Breast cancer brain metastasis

MicroRNAs

contributor

Lo, Hui-Wen (advisor)

Metheny-Barlow, Linda (committee member)

Kridel, Steven (committee member)

Sun, Peiqing (committee member)

Xing, Fei (committee member)

date

2024-05-23T08:36:22Z (accessioned)

2024 (issued)

degree

Cancer Biology (discipline)

embargo

2029-05-18 (terms)

2029-05-18 (liftdate)

identifier

http://hdl.handle.net/10339/109448 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation