Item Details

title

Mutational and Pathological Analysis of Brain Metastases in Lung Cancer Patients

author

Wang, Yuezhu

abstract

Lung cancer is the leading cause of cancer-related death worldwide, primarily due to the development of distant metastases, which reduce the five-year survival rate to 8.9%. Brain, bone, and liver are the most common metastatic sites. Lung cancer is classified into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) based on histological features. Although targeted therapies have improved survival for NSCLC patients with actionable mutations, effective treatments for patients without known driver mutations remain limited. Understanding the genetic mechanisms underlying metastasis is essential for advancing future therapies.

subject

genetic mutation

lung cancer

metastasis

prognosis

contributor

Xing, Fei (advisor)

Chan, Michael D (committee member)

Zhao, Dawen (committee member)

Singh, Ravi N (committee member)

Miller, Lance D (committee member)

date

2025-06-24T08:36:24Z (accessioned)

2025 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2027-06-23 (terms)

2027-06-23 (liftdate)

identifier

http://hdl.handle.net/10339/110999 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation