Item Details

title

Regenerative Medicine Therapies for Prevention of Abdominal Adhesions

author

Carmichael , Samuel Paterson

abstract

Introduction: Adhesions are fibrous bands of tissue that form between abdominal and pelvic structures following surgical interventions, trauma and sepsis. They develop in up to 90% of cases where the abdominal cavity is opened and are considered a major driver of hospital re-admissions. Studies indicate that nearly one third of laparotomy patients require re-hospitalization for adhesion-related causes within 5 years of the original insult. Minimally invasive laparoscopic techniques, barrier products and lysis of adhesions are employed for prevention and treatment of abdominal adhesions, but it is not clear whether these measures correlate to a reduction in the risk of adhesion-related complications. Thus, there is an urgent unmet need in reliable adhesion prevention strategies. The purpose of this dissertation is to develop a novel, clinically relevant rat model of abdominal adhesion formation, wherein we will test the application of human placental stem cell-based therapies for adhesions prevention.

subject

abdominal adhesions

animal model

bowel obstruction

hydrogel

regenerative medicine

stem cells

contributor

Atala, Anthony (advisor)

Almeida-Porada, Graca (committee member)

Parks, John S. (committee member)

Holcomb, John B. (committee member)

Soker, Shay (committee member)

date

2025-06-24T08:36:35Z (accessioned)

2025-06-24T08:36:35Z (available)

2025 (issued)

degree

Molecular Medicine and Translational Science (discipline)

identifier

http://hdl.handle.net/10339/111034 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation