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THE UTILITY OF PULSE PRESSURE MEASURED BY RADIAL ARTERIAL TONOMETRY IN DETERMINING CARDIOVASCULAR DISEASE IN ADULTS

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abstract
Elevated brachial PP is a surrogate measure for increased arterial stiffness and is associated with increased LVM and CHF. Pulse wave indices from radial arterial tonometry may be superior measures of arterial stiffness sequela compared to PPb. Relations of increased PPr with increased LVM in a cross-sectional was studied after adjustment for PPb. Second, relations of PPr with incident CHF over 4 years, was studied, after covariate adjustment in MESA. First, the multivariable models including PPb, PPr, and covariates for LVM/(height squared) (g/((meters squared)) positively related PPb and PPr to LVM (Beta = 0.14, 95% CI 0.11-0.17 for p < 0.0001 for PPb; and Beta = 0.13, 95% CI 0.10-0.16, p < 0.0001 for PPr). Second, Cox proportional hazards models showed a 1-SD increase of PPr (HR 1.29, CI 1.02-1.63), but not of PPb, DBP or SBP, were significantly associated with CHF after adjusting for covariates excluding LVM, ECG LVH or incident MI. After adjusting for LVM or ECG LVH, the association between PPr and incident CHF was no longer significant. There is no additional benefit in measuring PPr over PPb in assessing the sequela of arterial stiffness. However, in addition to PPb, PPr may be a useful surrogate measure for arterial stiffness.
subject
Cardiovascular medicine
Clinical Physiology
contributor
Prime, Darryl (author)
Byington, Bob (committee chair)
Herrington, David (committee member)
Ambrosius, Walter (committee member)
Carr, J. Jeffrey (committee member)
Brosnihan, K. Bridget (committee member)
date
2009-04-29T18:35:30Z (accessioned)
2010-06-18T18:59:12Z (accessioned)
2009-04-29T18:35:30Z (available)
2010-06-18T18:59:12Z (available)
2009-04-29T18:35:30Z (issued)
degree
Clinical Epidemiology & Health Services (discipline)
identifier
http://hdl.handle.net/10339/14837 (uri)
language
en_US (iso)
publisher
Wake Forest University
rights
Release the entire work for access only to the Wake Forest University system for one year from the date below. After one year, release the entire work for access worldwide. (accessRights)
title
THE UTILITY OF PULSE PRESSURE MEASURED BY RADIAL ARTERIAL TONOMETRY IN DETERMINING CARDIOVASCULAR DISEASE IN ADULTS
type
Thesis

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