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Poroviscoelastic Modeling of the Mechanical and Fluid Response of Liver Tissue in Unconfined Compression

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abstract
Crash injury prevention research has yielded many preventative measures that work in conjunction to protect vital areas of the human body. However, some of these methods of fatality prevention have been shown to increase injury frequency in other areas of the body, including the abdomen. Within the abdomen, the liver is particularly prone to injury due to its size and relatively fixed position. One known mode of injury to this organ is burst injury, caused by rapidly increasing fluid pressure within this highly vascular organ. Exploration of this type of injury has shown fluid pressure to correlate well to liver injury severity in perfused whole-organ rapid compression testing. This study aimed to address one level of liver multi-scale testing by conducting unconfined compression tests on unperfused and perfused tissue blocks. This data was then used in model development, leading to finite element models capable of predicting mechanical and fluid response in tissue specimens. This strategy serves as the foundation to future testing and model development, working towards higher compression rates, larger deformation and increased geometric complexity. The eventual goal is the integration of a liver model into a whole body model, allowing the advancement of high-fidelity virtual crash test dummies and improved vehicle safety.
subject
Multiscale
Mechanical Characterization
Liver
Hepatic Trauma
Constitutive Modeling
Biphasic
Porcine
Bovine
Perfusion
contributor
Raghunathan, Smitha (author)
Sparks, Jessica L. (committee chair)
Martin, R. Shayn (committee member)
Smith, Tom (committee member)
Stitzel, Joel D. (committee member)
date
2010-05-07T19:56:54Z (accessioned)
2010-06-18T18:59:46Z (accessioned)
2010-05-07T19:56:54Z (available)
2010-06-18T18:59:46Z (available)
2010-05-07T19:56:54Z (issued)
degree
Medical Engineering (discipline)
identifier
http://hdl.handle.net/10339/14888 (uri)
language
en_US (iso)
publisher
Wake Forest University
rights
Release the entire work for access only to the Wake Forest University system for one year from the date below. After one year, release the entire work for access worldwide. (accessRights)
title
Poroviscoelastic Modeling of the Mechanical and Fluid Response of Liver Tissue in Unconfined Compression
type
Thesis

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