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Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers

Welker, Mark E.

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abstract
A number of alkynols have been prepared by Sonogoshira coupling of propargyl alcohol to disubstituted aromatic halides. Chelation controlled addition of organometallic nucleophiles to these alkynols was then affected followed by the addition of sulfur dioxide. This methodology was used to prepare a number of oxathiolene oxides which have been screened as NQO1 (quinone oxidoreductase) inducers.
citation
3 (issue)
6 (volume)
contributor
Ying, Maben (author)
Smentek, Matthew G. (author)
Ma, Rong (author)
Day, Cynthia S. (author)
Torti, Suzy V. (author)
Welker, Mark E. (author)
date
2010-11-30T21:40:51Z (accessioned)
2010-11-30T21:40:51Z (available)
2009 (issued)
identifier
Ying, Maben; Smentek, Matthew G.; Ma, Rong; Day, Cynthia S.; Torti, Suzy V.; & Welker, Mark E. Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers. Letters in Organic Chemistry. 2009. 6, 3:242-251. (citation)
10.2174/157017809787893064 (doi)
http://hdl.handle.net/10339/30049 (uri)
publisher
Bentham Science Publishers
You are granted a non-exclusive, non-transferable license to use the Article under the terms of the Creative Commons license CC-BY 4.0. (license)
rights
https://creativecommons.org/licenses/by/4.0/ (uri)
source
Letters in Organic Chemistry
title
Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers
type
Article

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