Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers
Welker, Mark E.
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- abstract
- A number of alkynols have been prepared by Sonogoshira coupling of propargyl alcohol to disubstituted aromatic halides. Chelation controlled addition of organometallic nucleophiles to these alkynols was then affected followed by the addition of sulfur dioxide. This methodology was used to prepare a number of oxathiolene oxides which have been screened as NQO1 (quinone oxidoreductase) inducers.
- citation
- 3 (issue)
- 6 (volume)
- contributor
- date
- 2010-11-30T21:40:51Z (accessioned)
- 2010-11-30T21:40:51Z (available)
- 2009 (issued)
- identifier
- Ying, Maben; Smentek, Matthew G.; Ma, Rong; Day, Cynthia S.; Torti, Suzy V.; & Welker, Mark E. Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers. Letters in Organic Chemistry. 2009. 6, 3:242-251. (citation)
- 10.2174/157017809787893064 (doi)
- http://hdl.handle.net/10339/30049 (uri)
- publisher
- Bentham Science Publishers
- You are granted a non-exclusive, non-transferable license to use the Article under the terms of the Creative Commons license CC-BY 4.0. (license)
- rights
- https://creativecommons.org/licenses/by/4.0/ (uri)
- source
- Letters in Organic Chemistry
- title
- Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers
- type
- Article