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Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers

Welker, Mark E.

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title
Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers
author
Ying, Maben
author
Smentek, Matthew G.
author
Ma, Rong
author
Day, Cynthia S.
author
Torti, Suzy V.
author
Welker, Mark E.
abstract
A number of alkynols have been prepared by Sonogoshira coupling of propargyl alcohol to disubstituted aromatic halides. Chelation controlled addition of organometallic nucleophiles to these alkynols was then affected followed by the addition of sulfur dioxide. This methodology was used to prepare a number of oxathiolene oxides which have been screened as NQO1 (quinone oxidoreductase) inducers.
citation
3 (issue)
6 (volume)
date
2010-11-30T21:40:51Z (accessioned)
2010-11-30T21:40:51Z (available)
2009 (issued)
identifier
Ying, Maben; Smentek, Matthew G.; Ma, Rong; Day, Cynthia S.; Torti, Suzy V.; & Welker, Mark E. Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers. Letters in Organic Chemistry. 2009. 6, 3:242-251. (citation)
http://hdl.handle.net/10339/30049 (uri)
identifier
10.2174/157017809787893064 (doi)
publisher
Bentham Science Publishers
rights
https://creativecommons.org/licenses/by/4.0/ (uri)
rights
You are granted a non-exclusive, non-transferable license to use the Article under the terms of the Creative Commons license CC-BY 4.0. (license)
source
Letters in Organic Chemistry
type
Article

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