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Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor

Electronic Theses and Dissertations

abstract: Listeria monocytogenes (Lm) is an intracellular bacterial pathogen that is of consequence to pregnant women and immunocompromised individuals. Exploiting a niche, Lm gains access to the host cell cytosol via the pore forming toxin listeriolysin O (LLO) and infects a variety of cell types including dendritic cells (DC). Our laboratory and others have shown that optimal DC maturation occurs when Listeria gain access to the host cytosol, and this correlates with protective immunity.
subject: Dendritic cell; Innate immunity; Listeria monocytogenes; Neutrophil; Type I IFN response
contributor: Brzoza-Lewis, Kristina Lynn (author); Schwartz, Elizabeth H (committee chair); Fetrow, Jacquelyn S (committee member); Alexander-Miller, Martha A (committee member); Grayson, Jason M (committee member); McPhail, Linda C (committee member)
date: 2011-02-16T21:42:12Z (accessioned); 2011-03-30T14:04:37Z (available); 2010 (issued)
degree: Molecular Genetics & Genomics (discipline)
embargo: 2011-02-17 (terms)
identifier: http://hdl.handle.net/10339/30392 (uri)
language: en (iso)
publisher: Wake Forest University
title: Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
type: Dissertation