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Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor

Electronic Theses and Dissertations

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title
Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
author
Brzoza-Lewis, Kristina Lynn
abstract
Listeria monocytogenes (Lm) is an intracellular bacterial pathogen that is of consequence to pregnant women and immunocompromised individuals. Exploiting a niche, Lm gains access to the host cell cytosol via the pore forming toxin listeriolysin O (LLO) and infects a variety of cell types including dendritic cells (DC). Our laboratory and others have shown that optimal DC maturation occurs when Listeria gain access to the host cytosol, and this correlates with protective immunity.
subject
Dendritic cell
Innate immunity
Listeria monocytogenes
Neutrophil
Type I IFN response
contributor
Schwartz, Elizabeth H (committee chair)
Fetrow, Jacquelyn S (committee member)
Alexander-Miller, Martha A (committee member)
Grayson, Jason M (committee member)
McPhail, Linda C (committee member)
date
2011-02-16T21:42:12Z (accessioned)
2011-03-30T14:04:37Z (available)
2010 (issued)
degree
Molecular Genetics & Genomics (discipline)
embargo
2011-02-17 (terms)
identifier
http://hdl.handle.net/10339/30392 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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