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Improving the Robustness of Perfusion Imaging with Arterial Spin Labeling Magnetic Resonance Imaging

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abstract
Tissue function depends heavily on perfusion, a process which brings the blood supply to the tissue through the arterial system and removes the metabolic by-products via the veins. Abnormalities and disruptions in this process can have profound effects. Cerebral blood flow (CBF), a quantitative perfusion measurement in the brain in units of milliliters of blood per 100 grams of tissue per minute, can be used to understand complex neurophysiology and reveal neuropathology. Cerebral perfusion is conventionally measured with the use of an exogenous contrast agent that is invasive and has limited repeatability. A new class of technique, known as arterial spin labeling (ASL), uses the water molecules in the arterial blood as an endogenous tracer to measure CBF via magnetic resonance imaging. ASL is therefore completely non-invasive and has been widely adapted in both clinical and research environments.
subject
Arterial Spin Labeling
Cerebral Blood Flow
Image Acquisition
Magnetic Resonance Imaging
contributor
Tan, Huan (author)
Kraft, Robert A (committee chair)
Daunais, James B (committee member)
Hamilton, Craig A (committee member)
Hoge, W. Scott (committee member)
Plemmons, Robert J (committee member)
date
2011-02-16T21:42:23Z (accessioned)
2011-02-16T21:42:23Z (available)
2010 (issued)
degree
Biomedical Engineering (discipline)
identifier
http://hdl.handle.net/10339/30406 (uri)
language
en (iso)
publisher
Wake Forest University
title
Improving the Robustness of Perfusion Imaging with Arterial Spin Labeling Magnetic Resonance Imaging
type
Dissertation

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