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ROLE OF 12/15 LIPOXYGENASE EXPRESSION IN LIPID METABOLISM, ATHEROSCLEROSIS AND INSULIN RESISTANCE

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abstract
12/15 lipoxygenase (LO) is a member of a family of enzymes that can catalyze the stereospecific incorporation of oxygen into polyunsaturated fatty acids (PUFAs), forming a series of bioactive lipid mediators. Though lipid mediators produced by 12/15LO have the potential to affect lipid metabolism and atherosclerosis, the role of 12/15LO expression in these processes has not been elucidated.
subject
Atherosclerosis
Lipid metabolism
Lipoxygenase
Macrophage
contributor
Rong, Shunxing (author)
Parks, John S. (committee chair)
Rudel, Lawrence L. (committee member)
Temel, Ryan E. (committee member)
Shelness, Gregory S. (committee member)
date
2011-02-16T21:42:28Z (accessioned)
2011-06-10T08:30:11Z (available)
2010 (issued)
degree
Molecular Pathology (discipline)
embargo
2011-06-10 (terms)
identifier
http://hdl.handle.net/10339/30414 (uri)
language
en (iso)
publisher
Wake Forest University
title
ROLE OF 12/15 LIPOXYGENASE EXPRESSION IN LIPID METABOLISM, ATHEROSCLEROSIS AND INSULIN RESISTANCE
type
Dissertation

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