Item Details

title

The Role of Bps Polysaccharide in Bordetella Resistance to Host Innate Defenses

author

Love, Cheraton Fabrice

abstract

Bacteria face many challenges during infection of the host. Initiation of infection requires attachment to host surfaces. Bordetella species possess several virulence factors that mediate binding to the host such as filamentous hemagglutinin and pertactin. A crucial component of successful colonization is evasion of host defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms is the production of a matrix composed of extracellular polymers including proteins, DNA and polysaccharides. We have shown that the bps locus is required for biofilm formation and production of the Bordetella polysaccharide (Bps), a major constituent of Bordetella biofilms.

subject

antimicrobial peptides

biofilms

Bordetella

contributor

Deora, Rajendar (committee chair)

McPhail, Linda (committee member)

Parks, Griffith (committee member)

Alexander-Miller, Martha (committee member)

Kock, Nancy (committee member)

date

2011-02-16T21:42:30Z (accessioned)

2011-02-16T21:42:30Z (available)

2010 (issued)

degree

Microbiology & Immunology (discipline)

identifier

http://hdl.handle.net/10339/30417 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation