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KINESIN-MICROTUBULE INTERACTIONS DURING GLIDING ASSAYS UNDER MAGNETIC FORCE

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abstract
Conventional kinesin is a motor protein capable of converting the chemical energy of ATP into mechanical work. In the cell, this is used to actively transport vesicles through the intracellular matrix. The relationship between the velocity of a single kinesin, as it works against an increasing opposing load, has been well studied. The relationship between the velocity of a cargo being moved by multiple kinesin motors against an opposing load has not been established. A major difficulty in determining the force-velocity relationship for multiple motors is determining the number of motors that are moving a cargo against an opposing load.
subject
kinesin
magnet
microtubule
molecular motors
stall force
uniform magnetic force
contributor
Fallesen, Todd Landon (author)
Macosko, Jed C (committee chair)
Bonin, Keith D (committee member)
Carlson, Eric D (committee member)
Hantgan, Roy R (committee member)
date
2011-02-16T21:42:38Z (accessioned)
2011-03-30T14:04:37Z (available)
2010 (issued)
degree
Physics (discipline)
embargo
2011-03-29 (terms)
identifier
http://hdl.handle.net/10339/30429 (uri)
language
en (iso)
publisher
Wake Forest University
title
KINESIN-MICROTUBULE INTERACTIONS DURING GLIDING ASSAYS UNDER MAGNETIC FORCE
type
Dissertation

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