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THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES

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abstract
Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein critical for intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to lower blood cholesterol in humans. Recently, NPC1L1 deficiency or ezetimibe treatment has been shown to improve hepatic steatosis in rodents and humans without a defined mechanism. In the first project, we found that genetic inactivation of NPC1L1 in mice prevents high fat diet (HFD)-induced fatty liver by inhibiting hepatic de novo lipogenesis, at least in part, through protecting mice against HFD-induced insulin resistance and hyperinsulinemia, a state known to drive hepatic lipogenesis. .
subject
Cholesterol
Hepatic Steatosis
NPC1L1
Obesity
contributor
Jia, Lin (author)
Yu, Liqing (committee chair)
Rudel, Lawrence L (committee member)
Parks, John S (committee member)
Shelness, Gregory S (committee member)
Shi, Hang (committee member)
date
2011-02-16T21:42:40Z (accessioned)
2012-11-24T09:30:07Z (available)
2010 (issued)
degree
Molecular Pathology (discipline)
embargo
2012-11-24 (terms)
identifier
http://hdl.handle.net/10339/30432 (uri)
language
en (iso)
publisher
Wake Forest University
title
THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES
type
Dissertation

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