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Streptococcal colonization of host mucosal surfaces: a study of biofilm formation and dispersal

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abstract
Group A Streptococcus (GAS) is a Gram-positive pathogen that is the causative agent of a variety of human diseases. Infections include pharyngitis, otitis media, sepsis, a toxic-shock syndrome, necrotizing fasciitis, and the post-infectious sequelae acute rheumatic fever and acute rheumatic heart disease. Thus, rather than exploit a singular niche, GAS has evolved to colonize and disseminate within several physiologically distinct anatomical sites of the human host. Such versatility requires the ability to coordinately regulate the expression and production of numerous factors in rapid response to host and environmental signals in order to facilitate attachment, replication, and eventual dispersal (dissemination). Experimental evidence suggests that GAS forms biofilms during the colonization of a surface. A biofilm is a bacterial sessile community encased in an extracellular matrix and attached to a substratum or interface. Biofilms are inherently tolerant to host defenses and antibiotic therapies and often involved in chronic illness due to impaired clearance. It is estimated that upwards of 60% of all bacterial infections involve biofilms. Presently, little is known about GAS biofilm matrix composition, or the regulation of biofilm formation and dispersal.
subject
Biofilm
Group A Streptococcus
SpeB
Srv
Streptococcus pyogenes
Tonsil
contributor
Roberts, Amity L. (author)
Reid, Sean D (committee chair)
Deora, Rajendar (committee member)
Poehling, Katherine A (committee member)
Schwartz, Elizabeth Hiltbold (committee member)
Swords, W Edward (committee member)
date
2011-02-16T21:42:40Z (accessioned)
2012-11-17T09:30:06Z (available)
2010 (issued)
degree
Microbiology & Immunology (discipline)
embargo
2012-11-17 (terms)
identifier
http://hdl.handle.net/10339/30433 (uri)
language
en (iso)
publisher
Wake Forest University
title
Streptococcal colonization of host mucosal surfaces: a study of biofilm formation and dispersal
type
Dissertation

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