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The Effect of Haemophilus influenzae and Streptococcus pneumoniae coinfection on Otitis Media Disease Progression and Treatment Efficacy

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abstract
Otitis media is a major public health problem in pediatrics worldwide. It is the number one reason for pediatric office visits, new antibiotic prescriptions and surgery in children. The two most commonly isolated pathogens from otitis media infection are Haemophilus influenzae and Streptococcus pneumoniae. Once established, these bacteria can cause persistent and/or recurrent infections and are often refractory to antibiotic therapy. One hypothesis to explain this persistence is the presence of biofilm communities, which are inherently resistent to host clearance mechanisms and antibiotics. Biofilm formation by otopathogens has been demonstrated in vitro, in a chinchilla model of experimental otitis media and on human patient samples.
subject
beta lactam
biofilm
coinfection
Haemophilus influenzae
otitis media
Streptococcus pneumoniae
contributor
Weimer, Kristin (author)
Swords, W. Edward (committee chair)
High, Kevin P (committee member)
McCall, Charles E (committee member)
Grayson, Jason M (committee member)
date
2011-02-16T21:42:43Z (accessioned)
2011-02-16T21:42:43Z (available)
2010 (issued)
degree
Microbiology & Immunology (discipline)
identifier
http://hdl.handle.net/10339/30435 (uri)
language
en (iso)
publisher
Wake Forest University
title
The Effect of Haemophilus influenzae and Streptococcus pneumoniae coinfection on Otitis Media Disease Progression and Treatment Efficacy
type
Dissertation

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