PASSS: Protein Active Site Structure Search
Electronic Theses and Dissertations
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Item Details
- title
- PASSS: Protein Active Site Structure Search
- author
- Pryor, Edward E.
- abstract
- The Protein Structure Initiative, a project on the scale of the Human Genome Project aimed at protein structure determination, has successfully identified the structure of multiple human proteins. Unfortunately, knowledge of structure alone provides little insight into a protein's function within the body. A protein's function is defined by its active site, the area of the protein structure involved in the chemistry of its function. Because a protein's structure is related to its sequence, there currently exist many methods which compare protein sequences in an attempt to extrapolate function. Although effective for specific cases, there exist many documented instances where two proteins have similar structure and function, but dissimilar sequences. This occurs because structure determines the functionality of the protein, not the sequence.
- subject
- Parallel Programming
- Protein Active Sites
- Protein Data Bank
- Relational Database
- contributor
- Fetrow, Jacquelyn S. (committee chair)
- John, David J. (committee member)
- Salsbury, Jr., Freddie R. (committee member)
- Turkett, Jr., William H. (committee member)
- date
- 2011-07-14T20:34:52Z (accessioned)
- 2012-07-14T08:30:17Z (available)
- 2006 (issued)
- degree
- Computer Science (discipline)
- embargo
- 2012-07-14 (terms)
- identifier
- http://hdl.handle.net/10339/33417 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- type
- Thesis