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PASSS: Protein Active Site Structure Search

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title
PASSS: Protein Active Site Structure Search
author
Pryor, Edward E.
abstract
The Protein Structure Initiative, a project on the scale of the Human Genome Project aimed at protein structure determination, has successfully identified the structure of multiple human proteins. Unfortunately, knowledge of structure alone provides little insight into a protein's function within the body. A protein's function is defined by its active site, the area of the protein structure involved in the chemistry of its function. Because a protein's structure is related to its sequence, there currently exist many methods which compare protein sequences in an attempt to extrapolate function. Although effective for specific cases, there exist many documented instances where two proteins have similar structure and function, but dissimilar sequences. This occurs because structure determines the functionality of the protein, not the sequence.
subject
Parallel Programming
Protein Active Sites
Protein Data Bank
Relational Database
contributor
Fetrow, Jacquelyn S. (committee chair)
John, David J. (committee member)
Salsbury, Jr., Freddie R. (committee member)
Turkett, Jr., William H. (committee member)
date
2011-07-14T20:34:52Z (accessioned)
2012-07-14T08:30:17Z (available)
2006 (issued)
degree
Computer Science (discipline)
embargo
2012-07-14 (terms)
identifier
http://hdl.handle.net/10339/33417 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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