Item Details

title

PASSS: Protein Active Site Structure Search

author

Pryor, Edward E.

abstract

The Protein Structure Initiative, a project on the scale of the Human Genome Project aimed at protein structure determination, has successfully identified the structure of multiple human proteins. Unfortunately, knowledge of structure alone provides little insight into a protein's function within the body. A protein's function is defined by its active site, the area of the protein structure involved in the chemistry of its function. Because a protein's structure is related to its sequence, there currently exist many methods which compare protein sequences in an attempt to extrapolate function. Although effective for specific cases, there exist many documented instances where two proteins have similar structure and function, but dissimilar sequences. This occurs because structure determines the functionality of the protein, not the sequence.

subject

Parallel Programming

Protein Active Sites

Protein Data Bank

Relational Database

contributor

Fetrow, Jacquelyn S. (committee chair)

John, David J. (committee member)

Salsbury, Jr., Freddie R. (committee member)

Turkett, Jr., William H. (committee member)

date

2011-07-14T20:34:52Z (accessioned)

2012-07-14T08:30:17Z (available)

2006 (issued)

degree

Computer Science (discipline)

embargo

2012-07-14 (terms)

identifier

http://hdl.handle.net/10339/33417 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis