Item Details

title

SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES

author

SARMA, SAURAV JYOTI

abstract

This project delves into the mechanistic details of the photochemical reactions of alkoxy-anthraquinones in various media in order to devise potential applications of these photoreactions. Currently, Photodynamic therapy relies on the generation of singlet oxygen in cells which is not efficient under hypoxic conditions such as that in cancer cells. Development and optimization of a water soluble caged anthraquinone that can release a biocidic aldehyde, 4-HNE, upon photolysis, has been studied as a possible alternative to overcome this limitation of photodynamic therapy at present. The impact of variations in substitution, conditions and additives on the course of the mechanistic pathways involved in the process, are investigated.

subject

caged-anthraquinone

hydrogen abstraction

Norrish reaction

photo-Claisen

radical cyclization

single electron transfer

contributor

JONES, PAUL B (committee chair)

CONNER, WILLIAM E (committee member)

BIERBACH, ULRICH (committee member)

COLYER, CHRISTA L (committee member)

KING, STHEPHEN B (committee member)

date

2011-07-14T20:34:54Z (accessioned)

2012-07-14T08:30:17Z (available)

2011 (issued)

degree

Chemistry (discipline)

embargo

2012-07-14 (terms)

identifier

http://hdl.handle.net/10339/33419 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation