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SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES

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title
SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES
author
SARMA, SAURAV JYOTI
abstract
This project delves into the mechanistic details of the photochemical reactions of alkoxy-anthraquinones in various media in order to devise potential applications of these photoreactions. Currently, Photodynamic therapy relies on the generation of singlet oxygen in cells which is not efficient under hypoxic conditions such as that in cancer cells. Development and optimization of a water soluble caged anthraquinone that can release a biocidic aldehyde, 4-HNE, upon photolysis, has been studied as a possible alternative to overcome this limitation of photodynamic therapy at present. The impact of variations in substitution, conditions and additives on the course of the mechanistic pathways involved in the process, are investigated.
subject
caged-anthraquinone
hydrogen abstraction
Norrish reaction
photo-Claisen
radical cyclization
single electron transfer
contributor
JONES, PAUL B (committee chair)
CONNER, WILLIAM E (committee member)
BIERBACH, ULRICH (committee member)
COLYER, CHRISTA L (committee member)
KING, STHEPHEN B (committee member)
date
2011-07-14T20:34:54Z (accessioned)
2012-07-14T08:30:17Z (available)
2011 (issued)
degree
Chemistry (discipline)
embargo
2012-07-14 (terms)
identifier
http://hdl.handle.net/10339/33419 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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