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Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process

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abstract
Mesenchymal stem cells (MSC) are an important component of many tissue engineering and regenerative medicine (TE/RM) strategies. Their multipotential characteristics make them extremely useful as a source of cells for TE/RM applications. Adipose-derived stem cells (ADSC) represent one type of MSC and have many characteristics which make them a clinically relevant source of MSC. Specifically, in the field of bone tissue engineering (BTE), ADSC are commonly used for in vitro osteogenesis studies. Although these cells display similar characteristics as bone marrow-derived stem cells (BMSC), the mechanisms and pathways that these cells utilize to differentiate down the osteogenic pathway are still unclear. Specific differences exist between BMSC and ADSC osteogenesis; however more detailed analysis of how the two MSC types differ will be important for enhanced clinical relevance of ADSC. Chapter 1 of this work identified important components of ADSC osteogenesis, providing an osteogenesis template for Chapters 2 and 3 which focus on the modulation of ADSC osteogenesis.
subject
Bone
Extracellular matrix
Gene array
Osteogenesis
Stem cells
tissue engineering
contributor
Coan, Heather Adeline Bradbury (author)
Van Dyke, Mark (committee chair)
Soker, Shay (committee member)
Lively, Mark O (committee member)
Boyan, Barbara D (committee member)
date
2011-07-14T20:34:57Z (accessioned)
2011-07-14T20:34:57Z (available)
2011 (issued)
degree
Molecular Genetics & Genomics (discipline)
identifier
http://hdl.handle.net/10339/33421 (uri)
language
en (iso)
publisher
Wake Forest University
title
Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process
type
Dissertation

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