Item Details

abstract

Mesenchymal stem cells (MSC) are an important component of many tissue engineering and regenerative medicine (TE/RM) strategies. Their multipotential characteristics make them extremely useful as a source of cells for TE/RM applications. Adipose-derived stem cells (ADSC) represent one type of MSC and have many characteristics which make them a clinically relevant source of MSC. Specifically, in the field of bone tissue engineering (BTE), ADSC are commonly used for in vitro osteogenesis studies. Although these cells display similar characteristics as bone marrow-derived stem cells (BMSC), the mechanisms and pathways that these cells utilize to differentiate down the osteogenic pathway are still unclear. Specific differences exist between BMSC and ADSC osteogenesis; however more detailed analysis of how the two MSC types differ will be important for enhanced clinical relevance of ADSC. Chapter 1 of this work identified important components of ADSC osteogenesis, providing an osteogenesis template for Chapters 2 and 3 which focus on the modulation of ADSC osteogenesis.

subject

Bone

Extracellular matrix

Gene array

Osteogenesis

Stem cells

tissue engineering

contributor

Coan, Heather Adeline Bradbury (author)

Van Dyke, Mark (committee chair)

Soker, Shay (committee member)

Lively, Mark O (committee member)

Boyan, Barbara D (committee member)

date

2011-07-14T20:34:57Z (accessioned)

2011-07-14T20:34:57Z (available)

2011 (issued)

degree

Molecular Genetics & Genomics (discipline)

identifier

http://hdl.handle.net/10339/33421 (uri)

language

en (iso)

publisher

Wake Forest University

title

Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process

type

Dissertation