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In situ bioprinting of the skin

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abstract
Burn injury is a common source of morbidity and mortality in the battlefield, comprising 10 to 30% of all casualties. In the civilian population, there are approximately 500,000 burn injuries requiring treatment each year. Autografts and commercially available skin products are limited in size and some require a lengthy preparation time, making them unusable in severe cases that require prompt and aggressive measures to maintain the lives of wounded patients. Moreover, patient survival is inversely proportional to the amount of time required to cover and stabilize a wound. Therefore, a new approach that permits immediate burn wound stabilization with functional recovery is necessary. We propose a novel treatment that would repair burn wounds in situ by using cartridge-based bioprinting to precisely deliver skin cells in a controlled manner in a wound.
subject
bioprinting
regenerative medicine
skin
contributor
Binder, Kyle (author)
Yoo, James J (committee chair)
Soker, Shay (committee member)
Lively, Mark (committee member)
Holmes, James H (committee member)
Walker, Stephen (committee member)
date
2011-07-14T20:35:03Z (accessioned)
2012-07-14T08:30:18Z (available)
2011 (issued)
degree
Molecular Genetics & Genomics (discipline)
embargo
2012-07-14 (terms)
identifier
http://hdl.handle.net/10339/33425 (uri)
language
en (iso)
publisher
Wake Forest University
title
In situ bioprinting of the skin
type
Dissertation

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