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SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME

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title
SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME
author
Pandya, Hetal Vinod
abstract
Glioblastoma multiforme (GBM) is a primary brain tumor of dismal prognosis. Patients with GBM have a median survival rate of 14.5 months inspite of multimodality treatment involving surgery, radio- and chemotherapy. This warrants an intensive search for efficient new therapies. Interleukin 13 receptor alpha 2 (IL-13Rα2) is an internalized, plasma membrane receptor for IL-13. IL-13Rα2 is over-expressed in around 75 percent of GBM patients. One of our goals is to develop specific therapeutic delivery vehicles and imaging agents targeting IL-13Rα2.
subject
blood-brain tumor barrier
double-specificity
intracellular trafficking
phage display library
sub-cellular compartment delivery
tumor-associated antigen
contributor
Debinski, Waldemar (committee chair)
Dubey, Purnima (committee member)
Hantgan, Roy (committee member)
Kridel, Steven (committee member)
Lively, Mark (committee member)
date
2011-07-14T20:35:08Z (accessioned)
2012-01-14T09:30:11Z (available)
2011 (issued)
degree
Molecular Genetics & Genomics (discipline)
embargo
2012-01-14 (terms)
identifier
http://hdl.handle.net/10339/33429 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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