SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME
Electronic Theses and Dissertations
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Item Details
- abstract
- Glioblastoma multiforme (GBM) is a primary brain tumor of dismal prognosis. Patients with GBM have a median survival rate of 14.5 months inspite of multimodality treatment involving surgery, radio- and chemotherapy. This warrants an intensive search for efficient new therapies. Interleukin 13 receptor alpha 2 (IL-13Rα2) is an internalized, plasma membrane receptor for IL-13. IL-13Rα2 is over-expressed in around 75 percent of GBM patients. One of our goals is to develop specific therapeutic delivery vehicles and imaging agents targeting IL-13Rα2.
- subject
- blood-brain tumor barrier
- double-specificity
- intracellular trafficking
- phage display library
- sub-cellular compartment delivery
- tumor-associated antigen
- contributor
- Debinski, Waldemar (committee chair)
- Dubey, Purnima (committee member)
- Hantgan, Roy (committee member)
- Kridel, Steven (committee member)
- Lively, Mark (committee member)
- date
- 2011-07-14T20:35:08Z (accessioned)
- 2012-01-14T09:30:11Z (available)
- 2011 (issued)
- degree
- Molecular Genetics & Genomics (discipline)
- embargo
- 2012-01-14 (terms)
- identifier
- http://hdl.handle.net/10339/33429 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME
- type
- Dissertation