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Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ

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title
Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ
author
Pryor, Edward E.
abstract
The opportunistic pathogen Pseudomonas aeruginosa causes a myriad of infections to immunosuppressed patients, including endocarditis, microbial keratitis of the eye, pneumonia, urinary tract infections, and chronic lung infection in patients with cystic fibrosis. The underlying cause of the severity of these infections is due in part to the arsenal of virulence factors P. aeruginosa has at its disposal, which include biofilm formation, lipopolysaccharide, quorum sensing, and exotoxin production, among others. AmrZ, a member of the ribbon-helix-helix family of DNA binding proteins, regulates several virulence factors, including alginate biosynthesis, flagellum expression, and type IV pili localization and twitching motility. AmrZ also acts as an autorepressor by binding two sites on its own promoter.
subject
Crystallography
Cystic Fibrosis
Protein - DNA interactions
Structural Biology
Transcriptional Regulation
Virulence
contributor
Hollis, Thomas (committee chair)
Wozniak, Daniel J. (committee member)
Lyles, Douglas S. (committee member)
Poole, Leslie B. (committee member)
Fetrow, Jacquelyn S. (committee member)
Lowther, W. Todd (committee member)
date
2011-07-14T20:35:36Z (accessioned)
2012-07-14T08:30:19Z (available)
2011 (issued)
degree
Biochemistry and Molecular Biology (discipline)
embargo
2012-07-14 (terms)
identifier
http://hdl.handle.net/10339/33457 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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