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THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS

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abstract
Dietary omega-3 polyunsaturated fatty acids, primarily eicosapentaenoate (EPA) and docosahexaenoate (DHA), attenuate chronic diseases such as atherosclerosis. However, fatty fish, the richest dietary source of omega-3 fatty acids, is consumed in low quantities in the U.S. Therefore, we sought to determine whether a botanical oil, echium oil from Echium plantagineum that is enriched in stearidonic acid (SDA; 18:4 n-3), will alter monocyte and macrophage phenotypes in murine models of atherosclerosis. This dissertation addresses the considerable gaps in knowledge regarding the atheroprotective and anti-inflammatory potential of echium oil supplementation. Furthermore, this work helped elucidate the role of omega-3 fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids.
subject
alternative
echium oil
fish oil
inflammation
Ly6C
SDA
contributor
Brown, Amanda Lynn (author)
Parks, John S. (committee chair)
Dawson, Paul A. (committee member)
Alexander-Miller, Martha (committee member)
Seeds, Michael C. (committee member)
Mishra, Nilamadhab (committee member)
Yoza, Barbara A. (committee member)
date
2011-07-14T20:35:38Z (accessioned)
2012-07-14T08:30:17Z (available)
2011 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2012-07-14 (terms)
identifier
http://hdl.handle.net/10339/33459 (uri)
language
en (iso)
publisher
Wake Forest University
title
THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS
type
Dissertation

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