Item Details

title

THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS

author

Brown, Amanda Lynn

abstract

Dietary omega-3 polyunsaturated fatty acids, primarily eicosapentaenoate (EPA) and docosahexaenoate (DHA), attenuate chronic diseases such as atherosclerosis. However, fatty fish, the richest dietary source of omega-3 fatty acids, is consumed in low quantities in the U.S. Therefore, we sought to determine whether a botanical oil, echium oil from Echium plantagineum that is enriched in stearidonic acid (SDA; 18:4 n-3), will alter monocyte and macrophage phenotypes in murine models of atherosclerosis. This dissertation addresses the considerable gaps in knowledge regarding the atheroprotective and anti-inflammatory potential of echium oil supplementation. Furthermore, this work helped elucidate the role of omega-3 fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids.

subject

alternative

echium oil

fish oil

inflammation

Ly6C

SDA

contributor

Parks, John S. (committee chair)

Dawson, Paul A. (committee member)

Alexander-Miller, Martha (committee member)

Seeds, Michael C. (committee member)

Mishra, Nilamadhab (committee member)

Yoza, Barbara A. (committee member)

date

2011-07-14T20:35:38Z (accessioned)

2012-07-14T08:30:17Z (available)

2011 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2012-07-14 (terms)

identifier

http://hdl.handle.net/10339/33459 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation