Item Details

title

Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection

author

Beauchamp, Nicole

abstract

Unlike many other tissues, the lung is constantly assaulted with foreign antigens, both environmental and infectious. This includes a large number of viruses which spread via aerosolized droplets. In order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must be alerted to the presence of infection in the periphery. This occurs as a result of presentation of pathogen derived epitopes on professional antigen presenting cells (APC), primarily dendritic cells (DC). While an important role for dendritic cells (DC) as the activators of naive T cells is clear, the contribution of distinct DC subsets in this process is less understood. Multiple DC subsets are present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific CD8+ T cells following pulmonary viral infection.

subject

CD8 T cells

dendritic cells

lung

mouse

respiratory infection

vaccinia virus

contributor

Alexander-Miller, Martha A (committee chair)

Grayson, Jason (committee member)

Parks, Griffith (committee member)

High, Kevin (committee member)

Hiltbold-Schwartz, Elizabeth (committee member)

Barton, Erik (committee member)

date

2011-07-14T20:36:31Z (accessioned)

2012-07-14T08:30:19Z (available)

2011 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2012-07-14 (terms)

identifier

http://hdl.handle.net/10339/33501 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation