Item Details

title

Studies on the Application of Multiwalled Carbon Nanotubes for the Thermal Treatment of Cancer

author

Burke, Andrew Ryan

abstract

Nanomaterials are being investigated for use in a variety of biomedical applications relating to the treatment of diseases such as cancer. Carbon nanotubes in particular have been explored as drug delivery vectors, imaging contrast agents and mediators of tumor-specific thermal ablation when stimulated with near-infrared or radiofrequency energy. Several factors will influence their utility as nanomedicines, chiefly: their compatibility with normal tissues and their efficacy as therapeutic agents. In this thesis we investigated these aspects of the biomedical translation of carbon nanotubes (CNTs) through three aims: 1) To determine the role of chemical modifications in mediating blood toxicities during intravenous delivery, 2) To determine the cell type-specific effects of nanotube-mediated thermal treatments and 3) To determine the long-term efficacy of nanotube-mediated thermal treatments in a animal model of solid cancer.

subject

biocompatibility

cancer stem cell

nanoparticle

photothermal

thermal ablation

thrombosis

contributor

Torti, Suzy V (committee chair)

Soker, Shay (committee member)

Carroll, David L (committee member)

Seals, Darren F (committee member)

Sui, Guangchao (committee member)

date

2011-09-08T08:35:38Z (accessioned)

2011 (issued)

degree

Cancer Biology (discipline)

embargo

forever (terms)

10000-01-01 (liftdate)

identifier

http://hdl.handle.net/10339/36137 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation