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MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS

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abstract
The metabolic fate of newly absorbed cholesterol and phytosterols is orchestrated through the sterol transporter, adenosine triphosphate-binding cassette transporter G5/G8 heterodimer (G5/G8), and the cholesterol esterifying enzyme, acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and cholesterol absorption by reducing substrate availability for ACAT2 esterification.
subject
ABCG5/G8
ACAT2
Cholesterol absorption
chylomicron
lipoprotein metabolism
thoracic lymph duct cannulation
contributor
Nguyen, Tam Minh (author)
Rudel, Lawrence L (committee chair)
Parks, John S (committee member)
Kavanaugh, Kylie (committee member)
Brown, Jonathan M (committee member)
date
2011-09-08T08:35:47Z (accessioned)
2012-09-08T08:30:06Z (available)
2011 (issued)
degree
Molecular Pathology (discipline)
embargo
2012-09-08 (terms)
identifier
http://hdl.handle.net/10339/36144 (uri)
language
en (iso)
publisher
Wake Forest University
title
MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS
type
Dissertation

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