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THE INTERPLAY BETWEEN ESTROGENS AND THE NITRIC OXIDE SYSTEM IN CARDIAC FUNCTION AND STRUCTURE

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title
THE INTERPLAY BETWEEN ESTROGENS AND THE NITRIC OXIDE SYSTEM IN CARDIAC FUNCTION AND STRUCTURE
author
Jessup, Jewell
abstract
It is increasingly recognized that biological differences in the mechanisms regulating cardiovascular function in women and men critically impact the expression, clinical presentation, and outcomes of chronic diseases such as hypertension, diabetes, and heart failure. This is borne out from epidemiological and clinical studies that have explored the prevalence and presentation of heart disease in women, as well as a robust experimental literature demonstrating a role of estrogens in cardioprotection. Sex differences in mortality after myocardial infarction tell the story since data show a worse prognosis of death post-myocardial infarction for women (38% within the first year) compared to men (25% within the first year).
subject
BH4
Collagen
Diastolic Function
Estrogens
Nitric Oxide
contributor
Groban, Leanne (committee chair)
Robbins, Michael E.C. (committee member)
Shively, Carol A. (committee member)
Sane, David C. (committee member)
Chappell, Mark (committee member)
date
2011-09-08T08:36:01Z (accessioned)
2011-09-08T08:36:01Z (available)
2011 (issued)
degree
Physiology and Pharmacology (discipline)
identifier
http://hdl.handle.net/10339/36157 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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