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Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI

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abstract
Anthracycline chemotherapies induce nonfocal cardiac injury to the left ventricular (LV) myocardium. This damage, chemotherapy induced cardiotoxicity, is difficult to detect noninvasively prior to the advancement of injury to an irreversible state with decrements in left ventricular ejection fraction (LVEF). As cancer survival rates increase, the occurrence of chemotherapy induced cardiotoxicity is also increasing with reports of chronic heart failure rates of 3-36%, dependent on total dosage of chemotherapy. The recognition of the need to better manage the cardiovascular care of oncology patients and survivors of cancer has necessitated an emerging field, cardio-oncology, to bring the two areas of clinical practice together. The current noninvasive method of detecting cardiotoxicity, a decrement in LVEF, may occur before the extent of myocardial injury is irreversible. Safe, noninvasive methods for accurately detecting early evidence of myocardial injury are critically needed to prevent irreversible cardiotoxicity.
subject
Cardiotoxicity
Cardiovascular
Chemotherapy
Imaging
Magnetic Resonance
contributor
Jordan, Jennifer Hawthorne (author)
Hamilton, Craig A (committee chair)
Hundley, William G (committee member)
Kraft, Robert A (committee member)
Plemmons, Robert J (committee member)
Santago II, Peter (committee member)
date
2011-09-08T08:36:06Z (accessioned)
2013-09-08T08:30:10Z (available)
2011 (issued)
degree
Biomedical Engineering (discipline)
embargo
2013-09-08 (terms)
identifier
http://hdl.handle.net/10339/36164 (uri)
language
en (iso)
publisher
Wake Forest University
title
Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI
type
Dissertation

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