Item Details

abstract

Anthracycline chemotherapies induce nonfocal cardiac injury to the left ventricular (LV) myocardium. This damage, chemotherapy induced cardiotoxicity, is difficult to detect noninvasively prior to the advancement of injury to an irreversible state with decrements in left ventricular ejection fraction (LVEF). As cancer survival rates increase, the occurrence of chemotherapy induced cardiotoxicity is also increasing with reports of chronic heart failure rates of 3-36%, dependent on total dosage of chemotherapy. The recognition of the need to better manage the cardiovascular care of oncology patients and survivors of cancer has necessitated an emerging field, cardio-oncology, to bring the two areas of clinical practice together. The current noninvasive method of detecting cardiotoxicity, a decrement in LVEF, may occur before the extent of myocardial injury is irreversible. Safe, noninvasive methods for accurately detecting early evidence of myocardial injury are critically needed to prevent irreversible cardiotoxicity.

subject

Cardiotoxicity

Cardiovascular

Chemotherapy

Imaging

Magnetic Resonance

contributor

Jordan, Jennifer Hawthorne (author)

Hamilton, Craig A (committee chair)

Hundley, William G (committee member)

Kraft, Robert A (committee member)

Plemmons, Robert J (committee member)

Santago II, Peter (committee member)

date

2011-09-08T08:36:06Z (accessioned)

2013-09-08T08:30:10Z (available)

2011 (issued)

degree

Biomedical Engineering (discipline)

embargo

2013-09-08 (terms)

identifier

http://hdl.handle.net/10339/36164 (uri)

language

en (iso)

publisher

Wake Forest University

title

Early Identification of Chemotherapy Induced Cardiotoxicity Using Structural and Functional Cardiovascular MRI

type

Dissertation