Item Details

title

Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress

author

Juneau, Richard Anthony

abstract

Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal bacteria of the human nasopharynx. Normally residing in healthy individuals, NTHi rarely causes adverse effects. However, infection with NTHi in children often leads to middle ear inflammation and disease in the form of otitis media. A high frequency of doctor visits, antibiotic prescription, and drainage tube placement are due to childhood otitis media infections. Chronic obstructive pulmonary disease (COPD) is a restriction of airflow through the lungs and is often caused by cigarette smoking. In the United States, COPD is the fourth leading cause of death. NTHi is often found in patients suffering from COPD and it is implicated in exacerbation of disease. Since these diseases remain a health-care concern, it is important that we continue to study NTHi disease dynamics and host responses during the disease.

subject

COPD

Haemophilus influenzae

neutrophil extracellular trap

otitis media

PMN

contributor

Swords, William E (committee chair)

Reid, Sean (committee member)

Hiltbold-Schwartz, Elizabeth (committee member)

Haas, Karen (committee member)

date

2011-09-08T08:36:12Z (accessioned)

2012-09-08T08:30:06Z (available)

2011 (issued)

degree

Microbiology & Immunology (discipline)

embargo

2012-09-08 (terms)

identifier

http://hdl.handle.net/10339/36165 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation