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Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress

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abstract
Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal bacteria of the human nasopharynx. Normally residing in healthy individuals, NTHi rarely causes adverse effects. However, infection with NTHi in children often leads to middle ear inflammation and disease in the form of otitis media. A high frequency of doctor visits, antibiotic prescription, and drainage tube placement are due to childhood otitis media infections. Chronic obstructive pulmonary disease (COPD) is a restriction of airflow through the lungs and is often caused by cigarette smoking. In the United States, COPD is the fourth leading cause of death. NTHi is often found in patients suffering from COPD and it is implicated in exacerbation of disease. Since these diseases remain a health-care concern, it is important that we continue to study NTHi disease dynamics and host responses during the disease.
subject
COPD
Haemophilus influenzae
neutrophil extracellular trap
otitis media
PMN
contributor
Juneau, Richard Anthony (author)
Swords, William E (committee chair)
Reid, Sean (committee member)
Hiltbold-Schwartz, Elizabeth (committee member)
Haas, Karen (committee member)
date
2011-09-08T08:36:12Z (accessioned)
2012-09-08T08:30:06Z (available)
2011 (issued)
degree
Microbiology & Immunology (discipline)
embargo
2012-09-08 (terms)
identifier
http://hdl.handle.net/10339/36165 (uri)
language
en (iso)
publisher
Wake Forest University
title
Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress
type
Dissertation

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