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THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE

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abstract
The plasma concentration of apolipoprotein B (apoB)-containing lipoproteins is positively associated with several diseases, including atherosclerosis, type 2 diabetes and obesity. Hence, apoB may be a prime target for therapeutic intervention, particularly during its assembly. The molecular events associated with the initial formation of apoB-containing lipoproteins within the endoplasmic reticula of hepatic and intestinal cells are poorly understood. Earlier studies are consistent with a cotranslational lipid-desorption model that requires microsomal triglyceride transfer protein (MTP) and results in the formation of a small, neutral lipid core-containing emulsion particle. However, controversy exists as to the nature of the primordial lipoprotein and the requirement for MTP.
subject
adenovirus
apoB
atherosclerosis
MTP
contributor
Graves, Jason T. (author)
Shelness, Gregory S (committee chair)
Lowther, Todd (committee member)
Howard, Timothy (committee member)
date
2012-01-18T09:35:27Z (accessioned)
2014-01-18T09:30:11Z (available)
2011 (issued)
degree
Molecular Genetics & Genomics (discipline)
embargo
2014-01-18 (terms)
identifier
http://hdl.handle.net/10339/36423 (uri)
language
en (iso)
publisher
Wake Forest University
title
THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE
type
Thesis

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