Home WakeSpace Scholarship › Electronic Theses and Dissertations

THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE

Electronic Theses and Dissertations

Item Files

Item Details

title
THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE
author
Graves, Jason T.
abstract
The plasma concentration of apolipoprotein B (apoB)-containing lipoproteins is positively associated with several diseases, including atherosclerosis, type 2 diabetes and obesity. Hence, apoB may be a prime target for therapeutic intervention, particularly during its assembly. The molecular events associated with the initial formation of apoB-containing lipoproteins within the endoplasmic reticula of hepatic and intestinal cells are poorly understood. Earlier studies are consistent with a cotranslational lipid-desorption model that requires microsomal triglyceride transfer protein (MTP) and results in the formation of a small, neutral lipid core-containing emulsion particle. However, controversy exists as to the nature of the primordial lipoprotein and the requirement for MTP.
subject
adenovirus
apoB
atherosclerosis
MTP
contributor
Shelness, Gregory S (committee chair)
Lowther, Todd (committee member)
Howard, Timothy (committee member)
date
2012-01-18T09:35:27Z (accessioned)
2014-01-18T09:30:11Z (available)
2011 (issued)
degree
Molecular Genetics & Genomics (discipline)
embargo
2014-01-18 (terms)
identifier
http://hdl.handle.net/10339/36423 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

Usage Statistics