Item Details

title

THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE

author

Graves, Jason T.

abstract

The plasma concentration of apolipoprotein B (apoB)-containing lipoproteins is positively associated with several diseases, including atherosclerosis, type 2 diabetes and obesity. Hence, apoB may be a prime target for therapeutic intervention, particularly during its assembly. The molecular events associated with the initial formation of apoB-containing lipoproteins within the endoplasmic reticula of hepatic and intestinal cells are poorly understood. Earlier studies are consistent with a cotranslational lipid-desorption model that requires microsomal triglyceride transfer protein (MTP) and results in the formation of a small, neutral lipid core-containing emulsion particle. However, controversy exists as to the nature of the primordial lipoprotein and the requirement for MTP.

subject

adenovirus

apoB

atherosclerosis

MTP

contributor

Shelness, Gregory S (committee chair)

Lowther, Todd (committee member)

Howard, Timothy (committee member)

date

2012-01-18T09:35:27Z (accessioned)

2014-01-18T09:30:11Z (available)

2011 (issued)

degree

Molecular Genetics & Genomics (discipline)

embargo

2014-01-18 (terms)

identifier

http://hdl.handle.net/10339/36423 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis