Home WakeSpace Scholarship › Electronic Theses and Dissertations

The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes

Electronic Theses and Dissertations

Item Files

Item Details

abstract
Elevated levels of reactive oxygen species (ROS) have been observed in the cartilage of osteoarthritis (OA) patients and may contribute to the degradation of the articular cartilage extracellular matrix (ECM). ROS have been shown to serve as secondary messengers in integrin and cytokine signaling pathways which stimulate chondrocyte production of ECM-degrading enzymes called matrix metalloproteinases (MMPs). Fibronectin fragment (FN-f) stimulation of the &alpha5&beta1 integrin increases intracellular levels of ROS in chondrocytes, while antioxidants block FN-f stimulated MMP-13 expression, demonstrating ROS are critical regulators of this pathway. However, the means by which ROS regulate this pathway are unknown. Therefore, the objective of this work was to investigate the source of ROS and the mechanism by which ROS mediate the FN-f stimulation of MMP production.
subject
MAP kinases
matrix metalloproteinases
osteoarthritis
reactive oxygen species
redox signaling
sulfenic acid
contributor
Erickson, Elizabeth Alice (author)
Loeser, Richard F (committee chair)
Hantgan, Roy R (committee member)
McPhail, Linda C (committee member)
Poole, Leslie B (committee member)
Furdui, Cristina M (committee member)
date
2012-01-18T09:35:28Z (accessioned)
2011 (issued)
degree
Molecular Medicine and Translational Science (discipline)
10000-01-01 (liftdate)
embargo
forever (terms)
identifier
http://hdl.handle.net/10339/36425 (uri)
language
en (iso)
publisher
Wake Forest University
title
The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
type
Dissertation

Usage Statistics