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Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl

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abstract
Nitrogen oxides are a class of small molecules with profound physiological and environmental consequences. Nitric oxide (NO), the most well-known of these, is a key endogenous signaling agent effecting platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO.
subject
Angeli's salt
chemical ligation
fluorescence detection
kinetic analysis
nitrogen oxides
Staudinger
contributor
Reisz, Julie Ann (author)
King, S. Bruce (committee chair)
Alexander, Rebecca W (committee member)
Colyer, Christa L (committee member)
Poole, Leslie B (committee member)
Welker, Mark E (committee member)
date
2012-01-18T09:35:28Z (accessioned)
2014-01-18T09:30:11Z (available)
2011 (issued)
degree
Chemistry (discipline)
embargo
2014-01-18 (terms)
identifier
http://hdl.handle.net/10339/36426 (uri)
language
en (iso)
publisher
Wake Forest University
title
Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl
type
Dissertation

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