Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl
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- title
- Phosphine-Mediated Ligations: A Powerful and Versatile Method for the Selective Chemical Detection of Nitroxyl
- author
- Reisz, Julie Ann
- abstract
- Nitrogen oxides are a class of small molecules with profound physiological and environmental consequences. Nitric oxide (NO), the most well-known of these, is a key endogenous signaling agent effecting platelet disaggregation and vasorelaxation. Nitroxyl (HNO), the product of NO reduction and protonation, increases myocardial contractility and elicits vasodilation, likely through modifications of select thiol proteins, a physiological profile distinct from NO.
- subject
- Angeli's salt
- chemical ligation
- fluorescence detection
- kinetic analysis
- nitrogen oxides
- Staudinger
- contributor
- King, S. Bruce (committee chair)
- Alexander, Rebecca W (committee member)
- Colyer, Christa L (committee member)
- Poole, Leslie B (committee member)
- Welker, Mark E (committee member)
- date
- 2012-01-18T09:35:28Z (accessioned)
- 2014-01-18T09:30:11Z (available)
- 2011 (issued)
- degree
- Chemistry (discipline)
- embargo
- 2014-01-18 (terms)
- identifier
- http://hdl.handle.net/10339/36426 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- type
- Dissertation