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Circadian Influences in Cocaine Reinforcement

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abstract
Our central governing theme has been our belief that there is an endogenous circadian control that underlies (at least in part) self-administration behavior. This control can be over-ridden after extended self-administration and with higher dosing and access parameters. The neurobiological correlates of this control could prove to be a rewarding area of research in the search for better understanding, and ultimately better therapeutics, for drug addiction. The proceeding chapters of this dissertation are aimed elucidating some of the mechanism associated with circadian influences in cocaine reinforcement. The central themes that run throughout are 24-hour cocaine self-administration and the impact of time-of-day and brain cocaine levels on cocaine taking.
subject
circadian
cocaine
self-administration
contributor
Dobrin, Carson Virginia (author)
Roberts, David C.S. (committee chair)
Czoty, Paul W (committee member)
Howlett, Allyn (committee member)
Jones, Sara R (committee member)
McCool, Brian (committee member)
date
2012-01-18T09:35:33Z (accessioned)
2012-01-18T09:35:33Z (available)
2011 (issued)
degree
Neuroscience (discipline)
identifier
http://hdl.handle.net/10339/36436 (uri)
language
en (iso)
publisher
Wake Forest University
title
Circadian Influences in Cocaine Reinforcement
type
Dissertation

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