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SYNTHESIS AND SCREENING OF PI3K INHIBITOR PRODRUGS FOR TREATMENT OF PROSTATE CANCER

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abstract
Prostate cancer is the most common non-skin cancer in American men. At the current time, there is no effective treatment for men with metastatic prostate cancer. Androgen ablation is the most successful systemic treatment for prostate cancer. However, the cancer eventually recurs as androgen-independent prostate cancer. Phosphoinositide 3-kinases (PI3Ks) are involved in several imperative cellular functions such as growth and survival; therefore, inhibition of PI3K induces apoptosis (programmed cell death) and suppresses tumor growth. Several compounds have been identified as PI3K inhibitors, e.g., wortmannin, LY294002, and, ZSTK474, but all have low selectivity. We have addressed the specificity of current PI3K inhibitors by developing PSA (prostate-specific antigen)-activated analogues of known PI3K inhibitors LY294002 and ZSTK474.
subject
LY294002
PI3K inhibitor
ZSTK474
contributor
Pinder, Tanya (author)
Welker, Mark E. (committee chair)
Kulik, George (committee member)
Alexander, Rebecca W. (committee member)
Colyer, Christa L. (committee member)
Wright, Marcus W. (committee member)
date
2012-06-12T08:36:05Z (accessioned)
2013-06-12T08:30:11Z (available)
2012 (issued)
degree
Chemistry (discipline)
embargo
2013-06-12 (terms)
identifier
http://hdl.handle.net/10339/37309 (uri)
language
en (iso)
publisher
Wake Forest University
title
SYNTHESIS AND SCREENING OF PI3K INHIBITOR PRODRUGS FOR TREATMENT OF PROSTATE CANCER
type
Dissertation

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