RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO
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- abstract
- As a result of improvements in cancer therapy and health care, the population of long-term cancer survivors is growing. For these approximately 12 million long-term cancer survivors, brain metastases are a significant risk. Fractionated partial or whole-brain irradiation (fWBI) is often required to treat both primary and metastatic brain cancer. Radiation-induced normal tissue injury, including progressive cognitive impairment, however, can significantly affect the well-being of the approximately 200,000 patients who receive these treatments each year. Recent reports indicate that radiation-induced brain injury is associated with chronic inflammatory and oxidative stress responses, as well as increased microglial activation in the brain. Anti-inflammatory drugs may, therefore, be a beneficial therapy to mitigate radiation-induced brain injury. We hypothesized that activation of peroxisomal proliferator activated receptor delta (PPARä) would prevent or ameliorate radiation-induced brain injury, including cognitive impairment, in part, by alleviating inflammatory responses in microglia.
- subject
- Inflammation
- PPARdelta
- Radiation-Induced Brain Injury
- contributor
- Robbins, Michael E (committee chair)
- Townsend, Alan J (committee member)
- Sui, Guangchao (committee member)
- Chan, Michael D (committee member)
- date
- 2012-09-05T08:35:20Z (accessioned)
- 2012-09-05T08:35:20Z (available)
- 2012 (issued)
- degree
- Cancer Biology (discipline)
- identifier
- http://hdl.handle.net/10339/37442 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO
- type
- Dissertation