Item Details

abstract

As a result of improvements in cancer therapy and health care, the population of long-term cancer survivors is growing. For these approximately 12 million long-term cancer survivors, brain metastases are a significant risk. Fractionated partial or whole-brain irradiation (fWBI) is often required to treat both primary and metastatic brain cancer. Radiation-induced normal tissue injury, including progressive cognitive impairment, however, can significantly affect the well-being of the approximately 200,000 patients who receive these treatments each year. Recent reports indicate that radiation-induced brain injury is associated with chronic inflammatory and oxidative stress responses, as well as increased microglial activation in the brain. Anti-inflammatory drugs may, therefore, be a beneficial therapy to mitigate radiation-induced brain injury. We hypothesized that activation of peroxisomal proliferator activated receptor delta (PPARä) would prevent or ameliorate radiation-induced brain injury, including cognitive impairment, in part, by alleviating inflammatory responses in microglia.

subject

Inflammation

PPARdelta

Radiation-Induced Brain Injury

contributor

Schnegg, Caroline Isabel (author)

Robbins, Michael E (committee chair)

Townsend, Alan J (committee member)

Sui, Guangchao (committee member)

Chan, Michael D (committee member)

date

2012-09-05T08:35:20Z (accessioned)

2012-09-05T08:35:20Z (available)

2012 (issued)

degree

Cancer Biology (discipline)

identifier

http://hdl.handle.net/10339/37442 (uri)

language

en (iso)

publisher

Wake Forest University

title

RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO

type

Dissertation