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RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO

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abstract
As a result of improvements in cancer therapy and health care, the population of long-term cancer survivors is growing. For these approximately 12 million long-term cancer survivors, brain metastases are a significant risk. Fractionated partial or whole-brain irradiation (fWBI) is often required to treat both primary and metastatic brain cancer. Radiation-induced normal tissue injury, including progressive cognitive impairment, however, can significantly affect the well-being of the approximately 200,000 patients who receive these treatments each year. Recent reports indicate that radiation-induced brain injury is associated with chronic inflammatory and oxidative stress responses, as well as increased microglial activation in the brain. Anti-inflammatory drugs may, therefore, be a beneficial therapy to mitigate radiation-induced brain injury. We hypothesized that activation of peroxisomal proliferator activated receptor delta (PPARä) would prevent or ameliorate radiation-induced brain injury, including cognitive impairment, in part, by alleviating inflammatory responses in microglia.
subject
Inflammation
PPARdelta
Radiation-Induced Brain Injury
contributor
Schnegg, Caroline Isabel (author)
Robbins, Michael E (committee chair)
Townsend, Alan J (committee member)
Sui, Guangchao (committee member)
Chan, Michael D (committee member)
date
2012-09-05T08:35:20Z (accessioned)
2012-09-05T08:35:20Z (available)
2012 (issued)
degree
Cancer Biology (discipline)
identifier
http://hdl.handle.net/10339/37442 (uri)
language
en (iso)
publisher
Wake Forest University
title
RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO
type
Dissertation

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