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MATRIX METALLOPROTEINASES AND LEFT VENTRICLE MASS AND FUNCTION

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abstract
Introduction: Left Ventricle (LV) remodelling is critical pathophysiological process in the development of heart failure. Previous published studies have suggested the pivotal role of matrix metalloproteinases and NT- pro BNP in the pathogenesis of LV remodelling. Our objective was to establish a biomarker of cardiac extra cellular matrix (ECM) degradation that can be used to better identify asymptomatic individuals with increased LV mass, impaired LV volumes and functions and those at risk for progression to clinical heart failure.
subject
cardiac MRI
LV function
LV mass
Matrix metalloproteinase
NT-pro BNP
contributor
Rana, Hamza (author)
Burke, Gregory L (committee chair)
Carr, John J (committee member)
Chen, Haiying (committee member)
date
2012-09-05T08:35:21Z (accessioned)
2014-09-05T08:30:08Z (available)
2012 (issued)
degree
Clinical and Population Translational Sciences (discipline)
embargo
2014-09-05 (terms)
identifier
http://hdl.handle.net/10339/37444 (uri)
language
en (iso)
publisher
Wake Forest University
title
MATRIX METALLOPROTEINASES AND LEFT VENTRICLE MASS AND FUNCTION
type
Thesis

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