Item Details

abstract

The challenge of the cancer therapy remains in the lacking of efficient targeting of the malignant cells without causing significant systemic toxicity. Most of the clinically used cancer therapeutic agents circulates throughout the body causing sever damage including vital organ such as brain, liver, kidney limiting their usage. Moreover, due to drug resistance significant number of malignant cells survives even after the treatment with these conventional chemotherapies leaving the damage of systemic toxicity which may lead to metastasis. Recent studies demonstrated nano-sized complexes has the potential to deliver chemotherapeutics via indirect tumor targeting towards leaky tumor vasculature via Enhanced permiability and retention effect. Especially nanoparticles in combination with targetedly used therapeutic modalities such as Photo Dynamic Therapy (PDT) enhanced the efficacy of canceer therapy.

subject

Cancer Therapy

Drug Develoopment and Delivery

Nanotechnology

contributor

Ghosh, Supratim (author)

Gmeiner, William H (committee chair)

Lively, Mark O (committee member)

Kucera, Gregory L (committee member)

Howard, Timothy D (committee member)

Hellmann, Gary M (committee member)

date

2013-01-09T09:35:13Z (accessioned)

2015-01-09T09:30:09Z (available)

2012 (issued)

degree

Molecular Genetics & Genomics (discipline)

embargo

2015-01-09 (terms)

identifier

http://hdl.handle.net/10339/37661 (uri)

language

en (iso)

publisher

Wake Forest University

title

DEVELOPMENT OF A NOVEL CLASS MULTIMODALITY NANOPARTICLE AND CYTOTOXIC CONJUGATE FOR CANCER THERAPY

type

Dissertation