THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM
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- abstract
- Hepatic lipid metabolism plays a major role in non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. The primary goal of this work was to delineate the role of the hepatic cholesterol-esterifying enzyme acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in cholesterol balance and triglyceride metabolism.
- subject
- ACAT2
- cholesterol metabolism
- hepatic steatosis
- Non alcoholic fatty liver disease
- non biliary reverse cholesterol transport pathway
- Transintestinal cholesterol efflux pathway
- contributor
- Temel, Ryan E (committee chair)
- Dawson, Paul A (committee member)
- Brown, J Mark (committee member)
- Parks, John S (committee member)
- Rudel, Lawrence L (committee member)
- Shelness, Gregory (committee member)
- date
- 2013-06-06T21:19:25Z (accessioned)
- 2014-06-06T08:30:09Z (available)
- 2013 (issued)
- degree
- Molecular Pathology (discipline)
- embargo
- 2014-06-06 (terms)
- identifier
- http://hdl.handle.net/10339/38527 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM
- type
- Dissertation