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THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM

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title
THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM
author
Marshall, Stephanie Marie
abstract
Hepatic lipid metabolism plays a major role in non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. The primary goal of this work was to delineate the role of the hepatic cholesterol-esterifying enzyme acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in cholesterol balance and triglyceride metabolism.
subject
ACAT2
cholesterol metabolism
hepatic steatosis
Non alcoholic fatty liver disease
non biliary reverse cholesterol transport pathway
Transintestinal cholesterol efflux pathway
contributor
Temel, Ryan E (committee chair)
Dawson, Paul A (committee member)
Brown, J Mark (committee member)
Parks, John S (committee member)
Rudel, Lawrence L (committee member)
Shelness, Gregory (committee member)
date
2013-06-06T21:19:25Z (accessioned)
2014-06-06T08:30:09Z (available)
2013 (issued)
degree
Molecular Pathology (discipline)
embargo
2014-06-06 (terms)
identifier
http://hdl.handle.net/10339/38527 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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