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Influence of Weight Loss, Body Composition, and Lifestyle Behaviors on Plasma Adipokines: A Randomized Weight Loss Trial in Older Men and Women with Symptomatic Knee Osteoarthritis

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title
Influence of Weight Loss, Body Composition, and Lifestyle Behaviors on Plasma Adipokines: A Randomized Weight Loss Trial in Older Men and Women with Symptomatic Knee Osteoarthritis
author
Miller, Gary D.
author
Jenks, Monica Z.
author
Vendela, Mandolyn
author
Norris, James L.
author
Muday, Gloria K.
abstract
Objective. To investigate effects of weight loss on adipokines and health measures in obese older adults with symptomatic knee osteoarthritis. Methods. Participants were randomly assigned to either weight loss (WL) (men: 12, women: 14) or weight stable (WS) group (men: 12, women: 13). WL intervention included meal replacements and structured exercise training. Measurements of leptin, adiponectin, soluble leptin receptor, lifestyle behaviors, and body composition were collected at baseline and 6 months. Univariate analysis of covariance was performed on 6 month variables, and Spearman and partial correlations were made between variables. Results. Weight loss was 13.0% and 6.7% in WL for men and women, respectively. Women in WL had lower whole body and trunk fat than WS. The leptin : adiponectin ratio was lower for women in WL than WS at 6 months, with no group differences in adipokines for men. Leptin and free leptin index correlated with body fat in both genders at baseline. Interestingly, only women showed reductions in leptin ( ) and correlations between the percentage change leptin and trunk fat and the percentage changes in free leptin index with total fat and trunk fat. Partial correlations between 6 month adipokines after adjustments for covariates and group/time period show potential multivariate influences. Conclusions. In the presence of an effective weight loss intervention in older obese adults, there are significant relationships between weight and fat loss and leptin in women, but not men, suggesting gender-specific features of adipokine metabolism in this age group.
citation
2012 (volume)
date
2013-07-12T18:24:23Z (accessioned)
2013-07-12T18:24:23Z (available)
2012 (issued)
identifier
Gary D. Miller, Monica Z. Jenks, Mandolyn Vendela, James L. Norris, and Gloria K. Muday, “Influence of Weight Loss, Body Composition, and Lifestyle Behaviors on Plasma Adipokines: A Randomized Weight Loss Trial in Older Men and Women with Symptomatic Knee Osteoarthritis,” Journal of Obesity, vol. 2012, Article ID 708505, 14 pages, 2012. doi:10.1155/2012/708505 (citation)
Health and Exercise Science (other)
Biology (other)
Mathematics (other)
http://hdl.handle.net/10339/38640 (uri)
http://dx.doi.org/10.1155/2012/708505 (uri)
publisher
Hindawi
rights
https://creativecommons.org/licenses/by/3.0/ (uri)
source
Journal of Obesity
type
Article

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